Creatine, a skin’s own amino acid derivative, is produced from the amino acids arginine, glycine and methionine in the kidney, liver and pancreas and is mostly stored in muscle cells. As the endogenous creatine synthesis is not sufficient, creatine needs to be supplemented with the diet. Creatine acts as an energy buffer and supports the mitochondrial respiration system during times of increased energy demand: muscle cells store energy in the form of Creatine Phosphate and it is transported to tissue with high energy demands such as hair follicles.

Furthermore, Creatine activates cells to produce skin’s own collagen and elastin (in vitrodata) as these biomolecules are impaired in aged skin.