Creatine, a skin’s own amino acid derivative, is produced from the amino acids arginine, glycine and methionine in the kidney, liver and pancreas and is mostly stored in muscle cells. As the endogenous creatine synthesis is not sufficient, creatine needs to be supplemented with the diet. Creatine acts as an energy buffer and supports the mitochondrial respiration system during times of increased energy demand: muscle cells store energy in the form of Creatine Phosphate and it is transported to tissue with high energy demands such as hair follicles.

Furthermore, Creatine activates cells to produce skin’s own collagen and elastin (in vitrodata) as these biomolecules are impaired in aged skin.

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Arctiin is a naturally-derived active ingredient extracted from the fruit of the Burdock plant with anti-inflammatory  and anti-aging properties. 

Arctiin strengthens the connective  tissue by increasing the production of  the main extracellular matrix components collagen and hyaluronic acid as well as  inhibiting the degradation of elastase.  Additionally, Arctiin has anti-inflammatory properties.