Licochalcone A is a potent anti-inflammatory and antioxidant active that is derived from the roots of the Chinese licorice plant Glycyrrhiza inflata. Licochalcone A protects cells from oxidative stress mediated by UV and blue light (HEVIS).

Licochalcone A is able to activate anti-inflammatory, antioxidant and detoxifying enzymes. These enzymes protect the skin cells from damage induced by oxidative stress, like lipid peroxidation and DNA as wells as protein damage. Licochalcone A is able to soothe irritated skin and redness.

Glycyrrhetinic acid (also called Enoxolon) is derived from the roots of Glycyrrhiza glabra (licorice plant) and is well-known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti-inflammatory and antimicrobial properties.

Glycyrrhetinic acid helps to preserve the level of hyaluronic acid and elastin against enzymatic degradation by hyaluronidase. Furthermore supports the skin's own repair mechanism against UV-induced DNA damage.